hiCLIP (RNA hybrid and individual‐nucleotide resolution ultraviolet cross‐linking and immunoprecipitation), is a novel technique developed by Sugimoto et al. (2015). Here, the use of different adaptors permits a controlled ligation of the two strands of a RNA duplex allowing the identification of each arm in the duplex upon sequencing. The authors chose a notoriously difficult to study double‐stranded RNA‐binding protein (dsRBP) termed Staufen1, a mammalian homolog of Drosophila Staufen involved in mRNA localization and translational control. Using hiCLIP, they discovered a (...) dominance of intramolecular RNA duplexes compared to the total RNA duplexes identified. Importantly, the authors discovered two different types of intramolecular duplexes in the cell: highly translated mRNAs with long‐range duplexes in their 3′‐UTRs and poorly translated mRNAs with duplexes in their coding region. In conclusion, the authors establish hiCLIP as an important novel technique for the identification of RNA secondary structures that serve as in vivo binding sites for dsRBPs. (shrink)

For twenty years, the renowned philosopher of science Sandra Harding has argued that science and technology studies, postcolonial studies, and feminist critique must inform one another. In The Postcolonial Science and Technology Studies Reader, Harding puts those fields in critical conversation, assembling the anthology that she has long wanted for classroom use. In classic and recent essays, international scholars from a range of disciplines think through a broad array of science and technology philosophies and practices. The contributors reevaluate conventional (...) accounts of the West’s scientific and technological projects in the past and present, rethink the strengths and limitations of non-Western societies’ knowledge traditions, and assess the legacies of colonialism and imperialism. The collection concludes with forward-looking essays, which explore strategies for cultivating new visions of a multicultural, democratic world of sciences and for turning those visions into realities. Feminist science and technology concerns run throughout the reader and are the focus of several essays. Harding provides helpful background for each essay in her introductions to the reader’s four sections. Contributors Helen Appleton Karen Bäckstrand Lucille H. Brockway Stephen B. Brush Judith Carney Committee on Women, Population, and the Environment Arturo Escobar Maria E. Fernandez Ward H. Goodenough Susantha Goonatilake Sandra Harding Steven J. Harris Betsy Hartmann Cori Hayden Catherine L. M. Hill John M. Hobson Peter Mühlhäusler Catherine A. Odora Hoppers Consuelo Quiroz Jenny Reardon Ella Reitsma Ziauddin Sardar Daniel Sarewitz Londa Schiebinger Catherine V. Scott Colin Scott Mary Terrall D. Michael Warren. (shrink)

The logics BN4 and E4 can be considered as the 4-valued logics of the relevant conditional and (relevant) entailment, respectively. The logic BN4 was developed by Brady in 1982 and the logic E4 by Robles and Méndez in 2016. The aim of this paper is to investigate the implicative variants (of both systems) which contain Routley and Meyer’s logic B and endow them with a Belnap-Dunn type bivalent semantics.

Six interesting variants of the logics BN4 and E4—which can be considered as the 4-valued logics of the relevant conditional and entailment, respectively—were previously developed in the literature. All these systems are related to the family of relevant logics and contain Routley and Meyer's basic logic B, which is well-known to be specifically associated with the ternary relational semantics. The aim of this paper is to develop reduced general Routley-Meyer semantics for them. Strong soundness and completeness theorems are proved for (...) each one of the logics. (shrink)

Biblical spirituality must strike a delicate balance between historical-critical engagement with scripture and opening oneself to the Word's life-transforming potential.

"Dingli selects five particular contemporary philosophical topics which McDowell deals with and investigates in detail the implications of particular points of view, analysing the current literature on each topic and drawing out shortcomings and possibilities for overcoming them. This work is, then, both a critique and complement to McDowell's text."--Jacket.

There is a striking difference, however, between the ways female and male modernists define and describe literal or figurative costumes. Balancing self against mask, true garment against false costume, Yeats articulates a perception of himself and his place in society that most other male modernists share, even those who experiment more radically with costume as metaphor. But female modernists like Woolf, together with their post-modernist heirs, imagine costumes of the mind with much greater irony and ambiguity, in part because women's (...) clothing is more closely connected with the pressures and oppressions of gender and in part because women have far more to gain from the identification of costume with self or gender. Because clothing powerfully defines sex roles, both overt and covert fantasies of transvestism are often associated with the intensified clothes consciousness expressed by these writers. But although such imagery is crucially important in works by Joyce, Lawrence, and Eliot on the one hand, and in works by Barnes, Woolf, and H. D. on the other, it functions very differently for male modernists from the way it operates for female modernists.Sandra M. Gilbert, professor of English at the University of California at Davis, is the author of Acts of Attention: The Poems of D.H. Lawrence and In the Fourth World; the coauthor, with Susan Gubar, of The Madwoman in the Attic: The Woman Writer and the Nineteenth-Century Literary Imagination, and its sequel, No Man's Land: The Woman Writer and the Twentieth-Century Literary Imagination. (shrink)

A definition of [George] Eliot as renunciatory culture-mother may seem an odd preface to a discussion of Silas Marner since, of all her novels, this richly constructed work is the one in which the empty pack of daughterhood appears fullest, the honey of femininity most unpunished. I want to argue, however, that this “legendary tale,” whose status as a schoolroom classic makes it almost as much a textbook as a novel, examines the relationship between woman’s fate and the structure of (...) society in order to explicate the meaning of the empty pack of daughterhood. More specifically, this story of an adoptive father, an orphan daughter, and a dead mother broods on events that are actually or symbolically situated on the margins or boundaries of society, where culture must enter into a dialectical struggle with nature, in order to show how the young female human animal is converted into the human daughter, wife, and mother. Finally, then, this fictionalized “daughteronomy” becomes a female myth of origin narrated by a severe literary mother uses the vehicle of a half-allegorical family romance to urge acquiescence in the law of the Father.If Silas Marner is not obviously a story about the empty pack of daughterhood, it is plainly, of course, a “legendary tale” about a wanderer with a heavy yet empty pack. In fact, it is through the image of the packman that the story, in Eliot’s own words, “came across my other plans by a sudden inspiration”—and, clearly, her vision of this burdened outsider is a re-vision of the Romantic wanderer who haunts the borders of society, seeking a local habitation and a name.11 I would argue further, though, that Eliot’s depiction of Silas Marner’s alienation begins to explain Ruby Redinger’s sense that the author of this “fluid and metaphoric” story “is” both Eppie, the redemptive daughter, and Silas, the redeemed father. For in examining the outcast weaver’s marginality, this novelist of the “hidden life” examines also her own female disinheritance and marginality.12 11. Eliot to Blackwood, 12 Jan. 1861, quoted in Ruby V. Redinger, George Eliot: The Emergent Self , p. 436. As Susan Garber has suggested to me, the resonant image of the “packman” may be associated with the figure of Bob Jakin in The Mill on the Floss , the itinerant pack-bearing peddler who brings Maggie Tulliver a number of books, the most crucial of which is Tomas à Kempis’ treatise on Christian renunciation .12. Rediner, George Eliot, p. 439; Eliot, “Finale,” Middlemarch, p. 896. Sandra M. Gilbert, now professor of English at the University of California, Davis, will join the Department of English at Princeton University in fall 1985. Her most recent works include a collection of poems, Emily’s Bread , and, coedited with Susan Gubar, The Norton Anthology of Literature by Women: The Tradition in English . In addition, she is at work on Mother Rites: Studies in Literature and Maternity, a project from which “Life’s Empty Pack” is drawn, and, with Susan Gubar, on No Man’s Land: The Place of the Woman Writer in the Twentieth Century, a sequel to their collaborative Madwoman in the Attic: The Woman Writer and the Nineteenth-Century Literary Imagination . “Costumes of the Mind: Transvestitism as Metaphor in Modern Literature” appeared in the Winter 1980 issue of Critical Inquiry. (shrink)

We’d like to do a little hypnosis on you. Imagine that you’re ensconced in your own family room, your study, or your queen-sized bed. Settling back, you pick up the remote, flick on the TV, and naturally you turn to PBS. This is what you hear:Host 1: Good evening. Welcome to Masterpiece Theatre. Because Alistair Cooke is away on assignment in Alaska, we’ve agreed to host the show tonight, and that’s both a pleasure and a privilege because our program this (...) evening marks the beginning of a fascinating new series, a first on television: Masterpiece Theatre will present you with a docudrama entitled “Masterpiece Theatre.”Host 2: Like “The First Churchills,” this show analyzes the situation of real-life people—tonight, people in the academy. Names have not been changed to protect either the innocent or the guilty, but all the situations are fictive and at times words that may never have been spoken are put into the mouths of people who did not speak them. Other lines, however, are direct quotations from various written sources, although none of the characters, as we depict them, should be confused with any “actual” persons, whether or not those persons would scribe to the idea of their own reality. Like “Upstairs/Downstairs,” this program will introduce you to a spectrum of characters from many walks of life. What’s different about tonight’s episode, though, is that all these characters have passionate opinions about the show itself. Why, the very idea of Masterpiece Theatre drives some of them to Guerrilla Theatre, others to Theatre of the Absurd. Yes, you’ve always already guessed it: we focus tonight on a drama involving what we used to call humanists—now for some a dirty word—and most of our characters are in deep trouble. Sandra M. Gilbert, professor of English at the University of California, Davis, and Susan Gubar, professor of English at Indiana University, are coauthors of No Man’s Land: The Place of the Woman Writer in the Twentieth Century, Volume 1: The War of the Words and Volume II: Sexchanges , the first installments of a three-part sequel to their Madwoman in the Attic: The Woman Writer and the Nineteenth-Century Literary Imagination . They have also coedited The Norton Anthology of Literature by Women: The Tradition in English. (shrink)

That the pattern into which Lentricchia seeks to assimilate Stevens is politically charged becomes clearest when we turn to the following oddly incomprehensible statement: “In the literary culture that Stevens would create, the ‘phallic’ would not have been the curse word of some recent feminist criticism but the name of a limited, because male, respect for literature” . At the point where he makes this assertion, Lentricchia has been persuasively demonstrating that Stevens was “encouraged … to fantasize the potential social (...) authority of the literary as phallic authority” . But suddenly the critic’s measured discourse is disrupted by obviously personal feelings about the “curse word of some recent feminist criticism” and by a dazzlingly illogical definition of “respect for literature.” Such a disruption suggests that, in making his apparently objective argument about Stevens, Lentricchia has some other not so hidden agenda—and, of course, his peculiar decision to link his discussion of Stevens with an attack on The Madwoman in the Attic further supports this conclusion. What most strikingly reinforces the point, however, is the hysterical—or perhaps, with some recent feminist linguists, we should say “testerical”—rhetoric in which he couches his assault on our work.14 14. The term “testeria,” for male “hysteria,” is proposed by Juli Loesch in “Testeria and Penisolence—A Scourge to Humankind,” Aphra: The Feminist Literary Magazine, 4, 1 : 43-45; quoted in Casey Miller and Kate Swift, Words and Women: New Language in New Times , pp. 60-61. Sandra M. Gilbert, professor of English at Princeton University, and Susan Gubar, professor of English at Indiana University, are coauthors of No Man’s Land: The Place of the Woman Writer in the Twentieth Century, Volume I: The War of the Words , the first installment of a three-part sequel to their Madwoman in the Attic: The Woman Writer and the Nineteenth-Century Literary Imagination . They have also coedited The Norton Anthology of Literature by Women: The Tradition in English. (shrink)

In this original and stimulating study of Idealism, the dominant philosophical school of thought in late nineteenth-century Britain, Sandra den Otter interweaves philosophical and sociological concerns to make an important contribution to intellectual history.

In the story of Lazarus, Christian readers are invited and enabled to integrate the fear-inducing experience of death, that of loved ones and their own, into their faith vision.

Much of the literature on clinical ethical conflict has been specific to a specialty area or a particular patient group, as well as to a single profession. This study identifies themes of hospital nurses’ and physicians’ clinical ethical conflicts that cut across the spectrum of clinical specialty areas, and compares the themes identified by nurses with those identified by physicians. We interviewed 34 clinical nurses, 10 nurse managers and 31 physicians working at four different Canadian hospitals as part of a (...) larger study on clinical ethics committees and nurses’ and physicians’ use of these committees. We describe nine themes of clinical ethical conflict that were common to both hospital nurses and physicians, and three themes that were specific to physicians. Following this, we suggest reasons for differences in nurses’ and physicians’ ethical conflicts and discuss implications for practice and research. (shrink)

In this work we define, in a general way, an algebraic semantics for the logics of the hierarchy InPk. This semantics is defined by means of an alternative construction, with respect to the usual algebraic semantics, and it is known in the literature as Twist-structures semantics. Besides that, we modify such construction, defining the so-called ω-Twist-structures here. This adaptation allows us to prove adequacy theorems for every logic of the hierarchy InPk.

The logic BN4 can be considered as the 4-valued logic of the relevant conditional and the logic E4, as the 4-valued logic of entailment. The aim of this paper is to endow E4 with a 2-set-up Routley-Meyer semantics. It is proved that E4 is strongly sound and complete w.r.t. this semantics.

The multilinear extension of a cooperative game was introduced by Owen in 1972. In this contribution we study the Lovász extension for cooperative games by using the marginal worth vectors and the dividends. First, we prove a formula for the marginal worth vectors with respect to compatible orderings. Next, we consider the direct market generated by a game. This model of utility function, proposed by Shapley and Shubik in 1969, is the concave biconjugate extension of the game. Then we obtain (...) the following characterization: The utility function of a market game is the Lovász extension of the game if and only if the market game is supermodular. Finally, we present some preliminary problems about the relationship between cooperative games and combinatorial optimization. (shrink)

Valerie Plumwood introduced in "Some false laws of logic" a series of arguments on how the rules Exported Syllogism, Disjunctive Syllogism, Commutation, and Exportation are not acceptable. Based on this we define the class of Plumwood algebras - logical matrices that do not verify any of these theses. Afterwards we provide conditional variants of the characteristic matrix of the logic RM3 that are also Plumwood algebras. These matrices are given an axiomatization based on First Degree Entailment and are endowed with (...) Belnap-Dunn Semantics. Finally we provide results of Soundness and Completeness in the strong sense for each of the defined variants. (shrink)

Modern zoos strive to educate visitors about zoo animals and their wild counterparts’ conservation needs while fostering appreciation for wildlife in general. This research review examines how zoos influence those who visit them. Much of the research to-date examines zoo visitors’ behaviors and perceptions in relation to specific exhibits, animals and/or programs. In general, visitors have more positive perceptions and behaviors about zoos, their animals and conservation initiatives the more they interact with animals, naturalistic exhibits, and zoo programming/staff. Furthermore, zoo (...) visitors are receptive to conservation messaging and initiatives at zoos, and are more likely to participate in on-site conservation opportunities as opposed to after their visits. The research also suggests that repeat visitors are even more inclined to seek out conservation efforts compared to those visiting zoos for the first time. While current research suggests that repeat-visitors are more likely to engage in conservation efforts, little is known about causal factors related to such findings, and almost no research exists to-date comparing the conservation efforts of visitors vs. non-visitors. This latter comparison will likely play a greater role in future zoo visitor research, since it poses one of the most important metrics for evaluating the specific effects visiting a zoo can have on people engaging in conservation efforts in general. (shrink)

Idealism became the dominant philosphical school of thought in late nineteenth-century Britain. In this original and stimulating study, Sandra den Otter examines its roots in Greek and German thinking and locates it among the prevalent methodologies and theories of the period: empiricism and positivism, naturalism, evolution, and utilitarianism. In particular, she sets it in the context of the late nineteenth- and early twentieth-century debate about a science of society and the contemporary preoccupation with `community'.

In Sport Realism: A Law-Inspired Theory of Sport, Aaron Harper, Associate Professor of Philosophy at West Liberty University, introduces a new realist approach to conceptualize sport. The book is d...